Age-Centered Relationship anywhere between Blood circulation pressure and you can Cognitive Impairment: A combination-Sectional Investigation in the a rural Area of Xi’an, Asia

Blood pressure level are a modifiable exposure basis to have cognitive disability, as the matchmaking anywhere between blood pressure and you may cognitive handicap isn’t fully know. The goal of this study were to take a look at the the result of decades towards the relationships anywhere between hypertension and you will intellectual disability.


Hypertension and you may around the world cognitive setting suggestions try compiled away from 1799 players (decades 40–85) exactly who stayed in a community on suburbs of Xi’an, Asia, during the when you look at the-people interviews. Intellectual impairment is identified as a micro-Mental state Test (MMSE) get below the cutoff worth. The result of age toward relationship ranging from blood circulation pressure variables [systolic blood pressure (SBP), diastolic blood pressure level (DBP), mean arterial blood circulation pressure (MABP), and you may high blood pressure levels (HBP, SBP?140 mm Hg and you may/or DBP?ninety mm Hg)] and you may intellectual impairment was analyzed of the logistic regression patterns using telecommunications and stratified investigation. Hypertension and you can decades was thought to be one another continuous and categorical research.


A total of 231 participants were diagnosed as having cognitive impairment based on our criteria. Interaction analysis for the total population showed that SBP (when regarded as continuous data) was positively correlated with cognitive impairment (OR = 1.130 [95% CI, 1.028–1.242] per 10mmHg, P = 0.011); however, the age by SBP interaction term was negatively correlated with cognitive impairment (OR = 0.989 [95% CI, 0.982–0.997] per 10mmHg?year, P = 0.006), indicating that the relationship between SBP and cognitive impairment was age-dependent (OR = 1.130?0.989 (age-55.5) per 10mmHg,40 ?age?85). When the blood pressure and age were considered as binary data, the results were similar to those obtained when they were considered as continuous variables. Stratified multivariate analysis revealed that the relationship between SBP (when regarded as continuous data) and cognitive impairment was positive for patients aged 40–49 years (OR = 1.349 [95% CI: 1–1.753] per 10mmHg, P = 0.025) and 50–59 years (OR = 1.185 [95% CI: 1.028–1.366] per 10mmHg, P = 0.019), whereas it tended to be negative for patients aged 60–69 years (OR = 0.878 [95% CI: 0.729–1.058] per 10mmHg, P = 0.171) and ?70 years (OR = 0.927 [95% CI: 0.772–1.113] per 10mmHg, P = 0.416). Results similar to those for SBP were obtained for DBP, MABP and HBP as well. Subsequently, SBP, DBP and MABP were transformed into categorical data (SBP<140mmHg, 140mmHg?SBP<160mmHg, and SBP?160mmHg; DBP<90mmHg, 90mmHg?DBP<100mmHg, and DBP?100mmHg; MABP<100mmHg, 100mmHg?MABP<110mmHg, and MABP?110mmHg), and the stratified multivariate analysis was repeated. This analysis showed that the age-dependent association continued to exist and was especially prominent in the SBP?160 mmHg, DBP?90 mmHg and MABP?110 mmHg groups.


High blood pressure levels is positively correlated which have intellectual handicap about middle-old, but this positive connection refuses which have expanding age. Such overall performance revealed that particular blood pressure management strategies for some age range are crucial for keeping intellectual efforts.

Citation: Shang S, Li P, Deng Meters, Jiang Y, Chen C, Qu Q (2016) This-Dependent Dating anywhere between Blood pressure and you will Intellectual Disability: A corner-Sectional Data inside an outlying Section of Xi’an, Asia. PLoS That eleven(7): e0159485.

Copyright: © 2016 Shang ainsi que al. It is an open availableness blog post distributed in regards to the latest Imaginative Commons Attribution Licenses, and that it allows open-ended use, delivery, and reproduction in just about any typical, considering the original writer and you will origin is actually paid.

Studies Availableness: On account of constraints imposed because of the government of Mans Republic of China, analysis can not be produced in public places in reference to the latest Tort Responsibility Laws and Statistics Legislation. Studies supply was also restricted from the ethical approval to guard private information away from professionals. Someone wanting being able to access the content must discovered ethical acceptance away from medical Ethics Panel of your Basic Affiliated Medical of Xi’an Jiaotong University (). Requests for a de–understood study put from this investigation are taken to associated writer Qiumin Qu () shortly after finding moral approval.

Leave a Reply

Your email address will not be published.